EFFECT OF FORMULATION ON STABILITY OF FREEZE-DRIED RECOMBINANT HUMAN ALPHA-INTERFERON

Authors
MOREIRA T BARBERIA D GUTIERREZ A VEGA M PUJOL V SOTOLONGO J DUQUE J POMES R
Citation
T. Moreira et al., EFFECT OF FORMULATION ON STABILITY OF FREEZE-DRIED RECOMBINANT HUMAN ALPHA-INTERFERON, Cryo-letters, 16(5), 1995, pp. 275-282
Citations number
12
Categorie Soggetti
Biology Miscellaneous",Physiology
Journal title
Cryo-letters → ACNP
ISSN journal
01432044
Volume
16
Issue
5
Year of publication
1995
Pages
275 - 282
Database
ISI
SICI code
0143-2044(1995)16:5<275:EOFOSO>2.0.ZU;2-U
Abstract
The authors study the influence of two formulations on the stability o f freeze-dried recombinant human alpha interferon and on the crystalli zation of some excipients. Formulation B, containing glycine, was the most crystalline one. It also revealed higher stability. Due to the pr esence of dextran, formulation A was less crystalline than B. The decr ease in IFN stability could be ascribed to the formulation's high salt content.