Background: While an extensive literature documents the influence of d
epression on general medical services utilization, estimates of the ec
onomic burden of depression have focused on the direct costs of depres
sion treatment. Higher use of general medical services may contribute
significantly to the true cost of depressive illness. Methods: Compute
rized record systems of a large staff-model health maintenance organiz
ation (HMO) were used to identify consecutive primary care patients wi
th visit diagnoses of depression (n=6257) and a comparison sample of p
rimary care patients with no depression diagnosis (n=6257). The HMO ac
counting records were used to compare components of health care costs.
Results: Patients diagnosed as depressed had higher annual health car
e costs ($4246 vs $2371, P<.001) and higher costs for every category o
f care leg, primary care, medical specialty, medical inpatient, pharma
cy, laboratory). Similar cost differences were observed for each of th
e subgroups examined (patients treated with antidepressants, those not
treated with antidepressants, and those diagnosed at routine physical
examination visits). Pharmacy records indicated greater chronic medic
al illness in the diagnosed depression group, but large cost differenc
es remained after adjustment ($3971 vs $2644). Twofold cost difference
s persisted for at least 12 months after initiation of treatment. Conc
lusions: Diagnosis of depression is associated with a generalized incr
ease in use of health services that is only partially explained hy com
orbid medical conditions. In the primary care sector, this greater med
ical utilization exceeds direct treatment costs for depression. The pe
rsistence of utilization differences suggests that recognition and ini
tiation of treatment alone are not adequate to reduce utilization diff
erences.