RANKING OF CLINICAL AND CLINICAL PATHOLOG Y PARAMETERS OF THE COURSE OF THE DISEASE IN NEUROBORRELIOSIS

Whereas the diagnosis of acute neuroborreliosis by considering clinica l and cerebrospinal fluid parameters is very reliable chronic neurobor reliosis is an excluding diagnosis. The clinical symptoms are uncharac teristic, and there is no reliable laboratory test permitting a safe d iagnosis. Serological evidence of antibodies is no sign of activity of disease. Development of chronic infection after adequate treatment of acute neuroborreliosis seems to be very rare. We reinvestigated 15 pa tients half a year after antibiotic therapy of acute neuroborreliosis with regard to clinical and laboratory parameters. Most patients had a continous intrathecal IgG antibody production against Borrelia burgdo rferi, whereas no clinical signs of chronic neuroborreliosis existed. The antibody production against Borrelia burgdorferi must not be regar ded as a sign of chronic infection.