PREDICTION OF CHROMATOGRAPHIC PARAMETERS FOR SOME ANILINES BY MOLECULAR CONNECTIVITY

The possible relation existing between RF values obtained by thin-laye r chromatography for a group of anilines with connectivity indices pro posed by Kier and Hall has been studied. Using multivariable regressio n the corresponding connectivity functions, selected for their respect ive correlation coefficients, standard deviations, Snedecor's F and St udent's t were obtained. Regression analysis of the connectivity funct ions gives a correct prediction of the experimental elution sequence f or this group of substances on silica gel stationary phases and variou s mobile phases of different polarity. The corresponding random and st ability studies of the different prediction models selected were carri ed out, showing good stability and null randomness in all cases.