Jg. Copeland et al., CORRELATION OF CLINICAL EMBOLIC EVENTS WITH COAGULABILITY IN A PATIENT WITH A TOTAL ARTIFICIAL-HEART, The Journal of heart and lung transplantation, 14(5), 1995, pp. 990-998
A 46-year-old female patient was supported for 185 days with a total a
rtificial heart, underwent successful transplantation, and survived fo
r over 1 year with no clinical residual findings suggestive of embolic
events. Daily observation, analysis of a large battery of coagulation
tests, and eight serial computed tomographic scans suggest that she h
ad 12 embolic events while receiving mechanical support. Furthermore,
it appears that the events were associated temporally with several mil
d infections and that coagulation was stimulated several days to 1 wee
k before we detected the events.