VARIABILITY OF BRAIN LITHIUM LEVELS DURING MAINTENANCE TREATMENT - A MAGNETIC-RESONANCE SPECTROSCOPY STUDY

Authors
SACHS GS RENSHAW PF LAFER B STOLL AL GUIMARAES AR ROSENBAUM JF GONZALEZ RG
Citation
Gs. Sachs et al., VARIABILITY OF BRAIN LITHIUM LEVELS DURING MAINTENANCE TREATMENT - A MAGNETIC-RESONANCE SPECTROSCOPY STUDY, Biological psychiatry, 38(7), 1995, pp. 422-428
Citations number
22
Categorie Soggetti
Psychiatry
Journal title
Biological psychiatry → ACNP
ISSN journal
00063223
Volume
38
Issue
7
Year of publication
1995
Pages
422 - 428
Database
ISI
SICI code
0006-3223(1995)38:7<422:VOBLLD>2.0.ZU;2-Z
Abstract
In vivo magnetic resonance spectroscopy (MRS) was used to determine th e relationship between serum and brain lithium levels in bipolar patie nts (n = 25). Over the broad range of serum lithium levels observed, t he correlation (r =.68) with brain lithium levels was high, This corre lation was much weaker (r =.39) when limited to only those patients wi th serum lithium levels in the range of 0.6-1.0 mmol/l. This variabili ty may account for failure of lithium prophylaxis in some patients who have serum lithium levels in the therapeutic range.