C. Marcelli et al., THE RELATIONSHIP BETWEEN OSTEOARTHRITIS OF THE HANDS, BONE-MINERAL DENSITY, AND OSTEOPOROTIC FRACTURES IN ELDERLY WOMEN, Osteoporosis international, 5(5), 1995, pp. 382-388
To study the relationship between osteoarthritis (OA) and osteoporosis
(OP), radiographic osteoarthritis lesions of the hands (HOA) were qua
ntified in 300 healthy women, aged 75 years or more, as a subgroup of
a cohort originally recruited for a multicentre study of risk factors
for femoral neck fracture. The HOA combined score (i.e. the sum of the
grades of joint-space narrowing, osteophytes. erosions and joint misa
lignment), the osteophytosis score and the joint-space narrowing score
were calculated on a radiograph of both hands. Bone mineral density (
BMD) was measured using dual-energy X-ray absortiometry (Lunar DPX) at
the femoral neck, Ward's triangle and the total body. BMDs of the tot
al spine, lumbar spine, and the upper and lower limbs were derived fro
m the regional analyses of the total body measurement. Correlations be
tween bone mass, HOA scores and other variables were explored by multi
ple linear regression and stepwise logistic regression analysis. The H
OA combined score was positively correlated with increasing age but no
t with body mass index. In the multiple regression analyses the HOA co
mbined score positively correlated with BMD at all sites, except the f
emoral neck and Ward's triangle; the osteophytosis score correlated wi
th BMD at all sites; and no correlation was found between BMD and the
joint-space narrowing score. According to stepwise logistic regression
and after adjustment of BMD for age, women with an HOA combined score
higher than 20 had signficantly higher BMD values at all skeletal sit
es. Sixty-nine women (23%) reported a history of osteoporotic fracture
; among them, 20 (6.6%) reported a history of vertebral fracture. The
OA score of both subgroups was significantly lower than that of women
with no history of fracture. These data suggest that in elderly women
the severity of HOA is positively correlated with bone mass and that w
omen with a high score of HOA more rarely report a history of osteopor
otic fracture.