Aa. Kaipov et al., CHANGES OF THE LEFT-VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH ESSENTIAL-HYPERTENSION AFTER A COURSE OF ANTIHYPERTENSIVE TREATMENT, Kardiologia, 35(6), 1995, pp. 51-53
Patients with mild to moderate essential hypertension (n=29) were trea
ted for 6 week by antihypertensive drugs in individually effective dos
es. Eight patients received ebalapril, 8 - diltiazem, 7 - prazosin and
6 - nifedipine. None of the patients had signs of ischemic heart dise
ase, disorders of cardiac rhythm or heart failure. There was no differ
ence between four treatment groups in initial blood pressure and main
hemodynamic parameters. All the patients had echo-doppIer signs of dia
stolic dysfunction: isometric relaxation time and deceleration time of
early filling were increased, the peak early to peak atrial velocitie
s ratio was significantly decreased compared to values obtained in 15
healthy persons. In each of treatment groups therapy resulted in signi
ficant lowering of systolic and diastolic blood pressures and in a ten
dency to improvement of all echo-doppler characteristics of left ventr
icular diastolic function. Moreover, enalapril and diltiazem significa
ntly reduced isovolumic relaxation time while ebalapril also significa
ntly lowered peak early to peak atrial velocities ratio. #either nifed
ipine nor prazosine produced significant changes of left venrtcular di
astolic function. Dynamics of echo-doppler parameters of left ventricu
lar diastolic function during acute pharmacological test and during 6
weeks of treatment was not always identical. Peak to peak atrial ratio
was the most reliable parameter for prediction of reaction of left ve
ntricular diastolic function to course treatment. Its dynamics during
acute drug test coincided with that during 6 weeks of treatment in 75%
of cases.