F. Desangles et al., T(15-17) HYPERGRANULAR ACUTE PROMYELOCYTIC LEUKEMIA (M3) DEVELOPING INTO A T(3-6) M3 WITHOUT T(15-17) AT RELAPSE, Leukemia & lymphoma, 19(1-2), 1995, pp. 185
This report describes a case of acute promyelocytic leukemia (APL) M3.
At diagnosis, the specific t(15;17) translocation was observed. After
chemotherapy including retinoic acid, a complete remission was achiev
ed and the karyotype became normal. At relapse of the M3 leukemia, the
t(15;17) clone was no longer observed but a t(3;6) translocation was
then detected. Several hypotheses for this unusual cytogenetic course
of APL are discussed.