ALTERATION OF LYSOSOMAL MEMBRANE AND ENZYMES INDUCED BY PEPTIDOGLYCANMONOMER (PGM)

The influence of single (4 mg/mouse) and multiple (1 mg/mouse/day for 5 consecutive days) injections of PGM on some hepatic enzymes, lipid p eroxide generation in serum and liver and hepatic lysosomal membrane p ermeability was investigated. The studies performed showed that a sing le injection of PGM in vivo changed temporarily the permeability of ly sosomal membranes, lipid peroxidation products and, when administered in vitro, modulated superoxide anion production and did not affect the activity of lysosomal membrane enzymes. Multiple injections of PGM ca used no significant changes in the examined parameters. Although the m etabolic changes were time-limited and, from the toxicological point o f view provoked transient effects, the results obtained may be of impo rtance when using PGM in combined chemo-immunotherapy.