The amphibian Xenopus laevis is able to adapt to a dark background by
releasing melanophore-stimulating hormone (alpha-MSH) from the melanot
rope cells in the pars intermedia of the pituitary gland. This mechani
sm is being used as a model to study fundamentals of neuroendocrine in
formation processing. Recent data obtained from multidisciplinary stud
ies in our group on the functioning and hypothalamic regulation of Xen
opus melanotropes are reviewed.