EFFECT OF PACAP ON LH-RELEASE AND INTRACELLULAR CALCIUM MOBILIZATION IN PORCINE PITUITARY-CELLS

Authors
HIDALGODIAZ C DEAGUILAR JLG MARTINEZFUENTES AJ GARCIANAVARRO S GRACIANAVARRO F
Citation
C. Hidalgodiaz et al., EFFECT OF PACAP ON LH-RELEASE AND INTRACELLULAR CALCIUM MOBILIZATION IN PORCINE PITUITARY-CELLS, Netherlands journal of zoology, 45(1-2), 1995, pp. 166-168
Citations number
8
Categorie Soggetti
Zoology
Journal title
Netherlands journal of zoology → ACNP
ISSN journal
00282960
Volume
45
Issue
1-2
Year of publication
1995
Pages
166 - 168
Database
ISI
SICI code
0028-2960(1995)45:1-2<166:EOPOLA>2.0.ZU;2-B
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is suggeste d to control the activity of pituitary cells. Here we demonstrate that PACAP acts directly on gonadotrope cells increasing LH release, modul ating the action of Gonadotropin Releasing Hormone (GnRH) and inducing mobilization of free cytosolic calcium ([Ca2+](i)) PACAP could play a physiological role in the regulation of the hypothalamic-pituitary-go nadal axis.