ISOLATION AND SYNTHESIS OF TANYOLIDE-A AND TANYOLIDE-B, METABOLITES OF THE NUDIBRANCH SCLERODORIS-TANYA

The nudibranch Sclerodoris tanya, which was collected intertidally at La Jolla, contains two sesquiterpene glyceride esters, trinyolides A ( 4) and B (5). The structures of the tanyolides were elucidated by inte rpretation of spectral data. The absolute configuration of tanyolide B (5) was determined by synthesis of both enantiomers and the structure of tanyolide A (4) was also confirmed by synthesis. The tanyolides, w hich are located primarily in the dorsal mantle, deter feeding by two ecologically-relevant predatory fish.