GAMMA-INTERFERON IS CRITICAL FOR RESISTANCE TO THEILERS VIRUS-INDUCEDDEMYELINATION

Authors
RODRIGUEZ M PAVELKO K COFFMAN RL
Citation
M. Rodriguez et al., GAMMA-INTERFERON IS CRITICAL FOR RESISTANCE TO THEILERS VIRUS-INDUCEDDEMYELINATION, Journal of virology, 69(11), 1995, pp. 7286-7290
Citations number
37
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
11
Year of publication
1995
Pages
7286 - 7290
Database
ISI
SICI code
0022-538X(1995)69:11<7286:GICFRT>2.0.ZU;2-A
Abstract
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen per sistence in the spinal cord in susceptible SJL/J mice and completely a brogated resistance such that all C57BL/10SNJ mice developed demyelina tion, These experiments support the hypothesis that gamma interferon i s critically important for resistance to Theiler's virus-induced disea se but is not required for myelin destruction.