ELEMENTS OF THE POLYOMAVIRUS REPLICATION ORIGIN REQUIRED FOR HOMOLOGOUS RECOMBINATION MEDIATED BY LARGE T-ANTIGEN

Authors
LAURENT S BASTIN M
Citation
S. Laurent et M. Bastin, ELEMENTS OF THE POLYOMAVIRUS REPLICATION ORIGIN REQUIRED FOR HOMOLOGOUS RECOMBINATION MEDIATED BY LARGE T-ANTIGEN, Journal of virology, 69(11), 1995, pp. 7304-7308
Citations number
36
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
11
Year of publication
1995
Pages
7304 - 7308
Database
ISI
SICI code
0022-538X(1995)69:11<7304:EOTPRO>2.0.ZU;2-O
Abstract
We introduced various elements of the polyomavirus origin of DNA repli cation into the genome of rat cells, and we analyzed their capacity to elicit rearrangements within the integrated sequences when exposed to large T antigen. The cis-acting sequences required for homologous rec ombination were those that make up a functional replication origin.