We investigated the effects of a cognitive-behavioral treatment packag
e on reduction of anticipatory fear of pain during self-administered i
nsulin injections. Two patients diagnosed with insulin-dependent diabe
tes mellitus participated. An ABAB design was employed; the interventi
on conditions consisted of cue-controlled breathing, filmed modeling,
pacing, and reinforcement. A substantial reduction in the mean time fo
r injection and a reduction in behaviors indicative of anticipatory di
stress were achieved under intervention conditions. The clinical impor
tance of the study is discussed and areas for future research are iden
tified.