COMBINATION CHEMOTHERAPY WITH INTRAARTERIAL CISPLATIN AND DOXORUBICINPLUS INTRAVENOUS METHOTREXATE AND VINCRISTINE FOR LOCALLY ADVANCED BLADDER-CANCER

Purpose: We evaluate the usefulness of neoadjuvant chemotherapy for bl adder cancer. Materials and Methods: The usefulness of neoadjuvant, mo dified methotrexate, vinblastine, doxorubicin and cisplatin chemothera py was evaluated in 36 patients with locally advanced bladder cancer. Results: Of 36 patients 12 achieved a clinical complete response and 1 7 had a partial response. Of the 12 patients who achieved a clinical c omplete-response the bladder was preserved in 11 and all patients were disease-free at a median of 33 months. No significant toxicity was ob served. Conclusions: This chemotherapy is useful for locally advanced bladder cancer and the feasibility of bladder preservation in patients with a clinical complete response was suggested.