BENIGN PROSTATIC HYPERPLASIA SPECIFIC HEALTH-STATUS MEASURES IN CLINICAL RESEARCH - HOW MUCH CHANGE IN THE AMERICAN-UROLOGICAL-ASSOCIATION SYMPTOM INDEX AND THE BENIGN PROSTATIC HYPERPLASIA IMPACT INDEX IS PERCEPTIBLE TO PATIENTS
Mj. Barry et al., BENIGN PROSTATIC HYPERPLASIA SPECIFIC HEALTH-STATUS MEASURES IN CLINICAL RESEARCH - HOW MUCH CHANGE IN THE AMERICAN-UROLOGICAL-ASSOCIATION SYMPTOM INDEX AND THE BENIGN PROSTATIC HYPERPLASIA IMPACT INDEX IS PERCEPTIBLE TO PATIENTS, The Journal of urology, 154(5), 1995, pp. 1770-1774
Purpose: We assessed the relationship between changes in scores for th
e American Urological Association (AUA) symptom index and benign prost
atic hyperplasia (BPH) impact index with patient global ratings of imp
rovement in a large Veterans Affairs trial comparing different pharmac
ological therapies for BPH. Materials and Methods: The primary analyse
s compared absolute score changes from baseline with global ratings of
improvement-at 13 weeks for 1,218 men. Results: Subjects who rated th
emselves as being slightly improved had a mean decrease in AUA symptom
index and BPH impact index scores of 3.1 and 0.4 points, respectively
. However, the baseline scores strongly influenced this relationship.
Conclusions: These data provide guidance for investigators using the A
UA symptom index and BPH impact index as outcome measures.