Intravenous drug abuse related plexogenic pulmonary hypertension unass
ociated with recurrent thromboembolism or foreign-body granulomatous d
isease of the lung has not been previously reported. Herein, we descri
be the occurrence of fatal plexogenic pulmonary hypertension in a 33-y
ear-old Hispanic woman who had a history of chronic intravenous drug a
buse. In the absence of other known causes, cocaine-induced chronic va
soconstriction was the most probable pathogenic mechanism of plexogeni
c pulmonary hypertension in this patient.