AN INTEGRATED PHYSICAL MAP OF HUMAN-CHROMOSOME-16

We describe an integrated physical, genetic and cytogenetic map of hum an chromosome 16 comprising both a low-resolution megaYAC map and a hi gh-resolution cosmid contig/miniYAC map, which provides nearly complet e coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytogenetic breakpoint map and is in tegrated with genetic and gene transcript maps of the chromosome by se quence-tagged sites and clone hybridizations.