A HIGH-DENSITY YAC CONTIG MAP OF HUMAN-CHROMOSOME-22

Authors
COLLINS JE COLE CG SMINK LJ GARRETT CL LEVERSHA MA SODERLUND CA MASLEN GL EVERETT LA RICE KM COFFEY AJ GREGORY SG GWILLIAM R DUNHAM A DAVIES AF HASSOCK S TODD CM LEHRACH H HULSEBOS JM WEISSENBACH J MORROW B KUCHERLAPATI RS WADEY R SCAMBLER PJ KIM UJ SIMON MI PEYRARD M XIE YG CARTER NP DURBIN R DUMANSKI JP BENTLEY DR DUNHAM I
Citation
Je. Collins et al., A HIGH-DENSITY YAC CONTIG MAP OF HUMAN-CHROMOSOME-22, Nature, 377, 1995, pp. 367-379
Citations number
53
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
377
Year of publication
1995
Supplement
S
Pages
367 - 379
Database
ISI
SICI code
0028-0836(1995)377:<367:AHYCMO>2.0.ZU;2-5
Abstract
We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, esta blishing a single consensus. The map consists of all classes of DNA la ndmarks ordered on 705 yeast artificial chromosomes (YACs) at an avera ge landmark density of more than one per 70 kilobases. This map repres ents the practical limits of currently available YAC resources and pro vides the basis for determination of the entire gene content and genom ic DNA sequence of human chromosome 22.