ENANTIOSELECTIVE SYNTHESIS OF CHIRAL POLYFUNCTIONAL CYCLOPENTANE DERIVATIVES - EPOXY ESTERS, HYDROXY ESTERS, AND HYDROXY AMINO ESTERS

Enantiomeric epoxides have been synthetized in efficient and diastereo selective manner through the respective cycloadditions of diazomethane to the carbonyl group of antipodal cyclopentyl ketones. These epoxy d erivatives are potent synthetic building blocks which have been used a s versatile precursors to several enantiopure title compounds, these b eing molecules with a high functional density that bear, at least, fou r stereogenic centers in the cyclopentane ring and a quaternary stereo center in the side-chain.