ASSOCIATION STUDY OF SCHIZOPHRENIA AND THE IL-2 RECEPTOR-BETA CHAIN GENE

A case-control association study was conducted in Caucasian patients w ith schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 rece ptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorp hism in the IL-2R beta chain gene, were examined in both groups. No si gnificant differences in IL-BR concentrations or in the distribution o f the polymorphism were noted, This study does not support an associat ion between schizophrenia and the IL-2R beta gene locus, contrary to t he suggestive evidence from linkage analysis in multicase families. (C ) 1995 Wiley-Liss, Inc.