POTENTIAL LINKAGE DISEQUILIBRIUM BETWEEN SCHIZOPHRENIA AND LOCUS D22S278 ON THE LONG ARM OF CHROMOSOME-22

Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pai r analysis. In order to replicate these results, we performed the tran smission test for linkage disequilibrium (TDT) in 113 unrelated schizo phrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of t he marker AFM 182xd12 at the locus D22S278 (P = 0.02), The results of our study suggest a detectable oligogenic gene in a multigene system f or schizophrenia closely linked to D22S278 on the long arm of chromoso me 22. If confirmed by others, this finding could lead to the identifi cation of a schizophrenia susceptibility gene. (C) 1995 Wiley-Liss, In c.