RECEPTORS FOR CALCITONIN, CALCITONIN-GENE-RELATED PEPTIDE, AMYLIN, AND ADRENOMEDULLIN

Calcitonin, calcitonin gene related peptide, amylin, and adrenomedulli n are structurally related polypeptides characterized by a six or seve n amino acid ring structure linked by a disulfide bridge and an amidat ed C-terminus. They exhibit overlapping biological actions as a result of cross-reactivity between the different receptors. In this article, the respective receptors and G-protein-coupled postreceptor events ar e reviewed in relation to some of the biological actions of the peptid es.