Amylin has been demonstrated to decrease food intake in mice and rats.
Amylin is effective when delivered both peripherally and directly int
o the central nervous system. Amylin's effect on food intake is not av
ersive. Amylin may produce its effect on food intake by modulating nit
ric oxide synthesis. Calcitonin gene related peptide also decreases fo
od intake after peripheral and central administration. In addition, am
ylin has been demonstrated to modulate memory at both peripheral and c
entral sites.