APPROACHES TO NOVEL BICARBOCYCLIC NUCLEOSIDES

Approaches to the synthesis of a novel family of carbocyclic nucleosid es of potential anti-HIV interest have been developed. The key carbocy clic intermediate 9 was coupled with desired heterocyclic bases to giv e the corresponding bicyclic nucleosides. The structure of compound 9 and the bicarbocyclic dideoxynucleosides were confirmed by extensive H -1 and C-13 NMR studies including COSY, NOESY, DEFT and selective INEP T experiments.