ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENE-2-PIPERIDONES USING NOYORIS CATALYST - EFFECT OF N-SUBSTITUENTS ON THE ENANTIOSELECTIVITY

Citation
Jyl. Chung et al., ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENE-2-PIPERIDONES USING NOYORIS CATALYST - EFFECT OF N-SUBSTITUENTS ON THE ENANTIOSELECTIVITY, Tetrahedron letters, 36(41), 1995, pp. 7379-7382
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
36
Issue
41
Year of publication
1995
Pages
7379 - 7382
Database
ISI
SICI code
0040-4039(1995)36:41<7379:AHO3UN>2.0.ZU;2-4
Abstract
The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene -2-piperidones catalyzed by BINAP-Ru(II) complex was found to be signi ficantly effected by the internal substituents on the lactam nitrogen, affording the corresponding 3-alkyl-2-piperidones in 52-92% ee.