Jyl. Chung et al., ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENE-2-PIPERIDONES USING NOYORIS CATALYST - EFFECT OF N-SUBSTITUENTS ON THE ENANTIOSELECTIVITY, Tetrahedron letters, 36(41), 1995, pp. 7379-7382
The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene
-2-piperidones catalyzed by BINAP-Ru(II) complex was found to be signi
ficantly effected by the internal substituents on the lactam nitrogen,
affording the corresponding 3-alkyl-2-piperidones in 52-92% ee.