STEREOCONTROLLED SYNTHESIS OF THE PENTASACCHARIDE CORE STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN OLIGOSACCHARIDE BASED ON A HIGHLY CONVERGENT STRATEGY

Authors
DAN A ITO Y OGAWA T
Citation
A. Dan et al., STEREOCONTROLLED SYNTHESIS OF THE PENTASACCHARIDE CORE STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN OLIGOSACCHARIDE BASED ON A HIGHLY CONVERGENT STRATEGY, Tetrahedron letters, 36(41), 1995, pp. 7487-7490
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
41
Year of publication
1995
Pages
7487 - 7490
Database
ISI
SICI code
0040-4039(1995)36:41<7487:SSOTPC>2.0.ZU;2-M
Abstract
A highly convergent synthesis of the Man(3)GlcNAc(2) pentasaccharide s tructure 1 which is common to all asparagine-linked glycans is describ ed. p-Methoxybenzyl assisted beta-mannosidation was successfully appli ed to the coupling of trimannoside donor 3 and chitobiose derivative 4 to give the pentasaccharide 2 as a single isomer. Subsequent deprotec tion afforded the target compound 1.