SYNTHESIS OF GLUTAMATE AGONISTS AND ANTAGONISTS BY A RING SWITCHING STRATEGY

Authors
DINSMORE A DOYLE PM YOUNG DW
Citation
A. Dinsmore et al., SYNTHESIS OF GLUTAMATE AGONISTS AND ANTAGONISTS BY A RING SWITCHING STRATEGY, Tetrahedron letters, 36(41), 1995, pp. 7503-7506
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
41
Year of publication
1995
Pages
7503 - 7506
Database
ISI
SICI code
0040-4039(1995)36:41<7503:SOGAAA>2.0.ZU;2-#
Abstract
Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been mod ified to prepare L-alanine derivatives substituted at the beta-carbon atom with six-membered heteroaromatic rings. The pyrimidinone (11, R = R(1) = R(2) = H) has been shown to be a glutamate agonist and the com pound (13) to be an antagonist.