THE SYNTHESIS OF HYDROISOXAZOLO[2,3-D][1,4]BENZODIAZEPIN-6(5H)-ONES AND A,9B-TETRAHYDROISOXAZOLO[4,3-C]QUINOLIN-4(5H)-ONES

Authors
BOURKE S HEANEY F
Citation
S. Bourke et F. Heaney, THE SYNTHESIS OF HYDROISOXAZOLO[2,3-D][1,4]BENZODIAZEPIN-6(5H)-ONES AND A,9B-TETRAHYDROISOXAZOLO[4,3-C]QUINOLIN-4(5H)-ONES, Tetrahedron letters, 36(41), 1995, pp. 7527-7530
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
41
Year of publication
1995
Pages
7527 - 7530
Database
ISI
SICI code
0040-4039(1995)36:41<7527:TSOHA>2.0.ZU;2-U
Abstract
The reaction of various ethyl [2-(1-hydroxyiminoalkyl)phenyl]carbamoyl ]acrylates (2) with electron deficient olefins proceeds via a sequenti al dipole formation, dipolar cycloaddition sequence to furnish the hyd roisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and tetrahydroisoxazol o[4,3-c]quinolin-4(5H) (4) and (6). The product distribution reflects the nature of the reacting olefin and the position and extent of subst itution on the acrylate moiety.