APPLICATION OF CHEMICAL P450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .9. NOVEL OXIDATIVE PATHWAY OF PARASUBSTITUTED PHENOLS IN CYTOCHROME-P450 CHEMICAL-MODEL - SUBSTITUENT ELIMINATION ACCOMPANYING IPSO-SUBSTITUTION BY THE OXYGEN-ATOM OF THE ACTIVE SPECIES

Authors
OHE T MASHINO T HIROBE M
Citation
T. Ohe et al., APPLICATION OF CHEMICAL P450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .9. NOVEL OXIDATIVE PATHWAY OF PARASUBSTITUTED PHENOLS IN CYTOCHROME-P450 CHEMICAL-MODEL - SUBSTITUENT ELIMINATION ACCOMPANYING IPSO-SUBSTITUTION BY THE OXYGEN-ATOM OF THE ACTIVE SPECIES, Tetrahedron letters, 36(42), 1995, pp. 7681-7684
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
42
Year of publication
1995
Pages
7681 - 7684
Database
ISI
SICI code
0040-4039(1995)36:42<7681:AOCPMS>2.0.ZU;2-W
Abstract
The so-tetrakis(2,6-difluorophenyl)porphinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent eli mination from various para-substituted phenols. An experiment using [O -18]mCPBA proved that these reactions are accompanied with ipso-substi tution by the oxygen atom of the active species of the P450 model.