INTEGRIN STIMULATION DECREASES TYROSINE PHOSPHORYLATION AND ACTIVITY OF FOCAL ADHESION KINASE IN THYMOCYTES

Authors
KANAZAWA S ILIC D NOUMURA T YAMAMOTO T AIZAWA S
Citation
S. Kanazawa et al., INTEGRIN STIMULATION DECREASES TYROSINE PHOSPHORYLATION AND ACTIVITY OF FOCAL ADHESION KINASE IN THYMOCYTES, Biochemical and biophysical research communications, 215(2), 1995, pp. 438-445
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
215
Issue
2
Year of publication
1995
Pages
438 - 445
Database
ISI
SICI code
0006-291X(1995)215:2<438:ISDTPA>2.0.ZU;2-5
Abstract
FAK, focal adhesion kinase, is expressed in a variety of cell types an d has been suggested to transduce signals brought about by integrin-ex tracellular matrix (ECM) interactions, Integrin stimulation increases tyrosine phosphorylation and activity of FAK in all the cells examined to date. In contrast, in thymocytes stimulation of VLA-4 (alpha(4) be ta(1)) and LFA-1 (alpha(L) beta(2)) resulted in a marked decrease in t yrosine phosphorylation and activity of FAK. (C) 1995 Academic Press, Inc.