DECREASED BETA-ADRENERGIC STIMULATION OF GLYCOPROTEIN-SECRETION IN CFMICE SUBMANDIBULAR GLANDS - REVERSAL BY THE METHYLXANTHINE, IBMX

Citation
Cl. Mills et al., DECREASED BETA-ADRENERGIC STIMULATION OF GLYCOPROTEIN-SECRETION IN CFMICE SUBMANDIBULAR GLANDS - REVERSAL BY THE METHYLXANTHINE, IBMX, Biochemical and biophysical research communications, 215(2), 1995, pp. 674-681
Citations number
26
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006291X
Volume
215
Issue
2
Year of publication
1995
Pages
674 - 681
Database
ISI
SICI code
0006-291X(1995)215:2<674:DBSOGI>2.0.ZU;2-#
Abstract
beta-adrenergic stimulation of glycoprotein secretion was shown to be decreased in submandibular glands of Cystic Fibrosis (CF) mice, The de fective response was partially restored by the methylxanthine, IBMX or cpt-cyclic AMP. Cholinergic stimulation of pancreatic amylase secreti on was not affected in CF mice, demonstrating that this is not a gener alised depression of protein secretion. The data are the first to show that the CF mouse mimics the protein secretion defect in CF human sub mandibular cells and that the mechanism of correction of the CF defect is via elevation of cyclic AMP. The results are therefore invaluable towards devising a rational pharmaceutical therapy for CF patients. (C ) 1995 Academic Press, Inc.