INTRAVENOUS ALBUMIN PREVENTS MODERATE-SEVERE OVARIAN HYPERSTIMULATIONIN IN-VITRO FERTILIZATION PATIENTS - A PROSPECTIVE, RANDOMIZED AND CONTROLLED-STUDY

Objective: To assess the effectiveness of intravenous administration o f albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program. Study Design: Prospect ive randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 mi human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28). Results: Pati ents were similar in terms of cycle characteristics. No moderate-sever e OHSS developed in Group A whereas one severe OHSS case and four mode rate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group. Conclusion : Human albumin proves effectiveness in prevention of moderate-severe OHSS. Copyright (C) 1996 Elsevier Science Ireland Ltd.