IDENTIFICATION AND CLONING OF THE G3B CDNA-ENCODING A 3'-SEGMENT OF APROTEIN-BINDING TO GATA-3

The transcription factor GATA-3 contributes to the expression of sever al genes critical for T-cell function and development, including the T -cell receptor alpha and beta chains. We report here the isolation of a human cDNA clone which encodes a 3' segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact wi th GATA-3 in vitro, Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.