SOME RECENT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SEPARATIONS OF THEENANTIOMERS OF PHARMACEUTICALS AND OTHER COMPOUNDS USING THE WHELK-O 1 CHIRAL STATIONARY-PHASE

The Whelk-O 1 chiral stationary phase is generally useful for the chro matographic separation of the enantiomers of many classes of analytes including aryl propionic acid non-steroidal anti-inflammatory drugs, a ryl epoxides, sulfoxides, alcohols, amides and esters. We herein repor t some additional recent enantioseparations obtained with this column, including a number of pharmaceuticals such as thalidomide, nicardipin e, isradipine, mephenytoin, nirvanol, cyclandelate, bendroflumethiazid e, bupivicaine, tolperisone, proglumide, tropicamide and indapamide. T he separation of the enantiomers of a collection of additional analyte s is also reported, including several compounds containing basic nitro gen, a heretofore difficult class of compounds to resolve with this co lumn.