MIB1 IN COLORECTAL CARCINOMAS - ITS EVALUATION BY 3 DIFFERENT METHODSREVEALS LACK OF PROGNOSTIC-SIGNIFICANCE

Immunohistochemically detected MIB1 has been determined in a series of 106 colorectal carcinomas with three different evaluation methods (se miquantitative estimation, evaluation by image analysis, and cell coun t). Although the semiquantitative estimation correlated significantly with results obtained by image analysis (R = 0.8), both methods were o nly poorly associated with MIBI counts (R = 0.5). Additionally, all th ree methods revealed no statistical correlation of MIB1 with the clini cal outcome of the respective patients. Our results indicate a pronoun ced heterogeneity of MIB1 in colorectal adenocarcinoma, thus leading, irrespectively of the evaluation method used, to non-representative re sults with lack of clinical relevance. Copyright (C) 1996 Elsevier Sci ence Ireland Ltd.