FIA-AAS DETERMINATION OF SALICYLIC-ACID BY A SOLID-PHASE REACTOR OF COPPER CARBONATE INCORPORATED IN POLYESTER RESIN BEADS

The determination of salicylic acid was carried out by reaction of the drug with copper carbonate entrapped in a polymeric material in a sol id-phase reactor; the released cupric ions were monitored by flame ato mic absorption at 324.8 nm. The calibration graph is linear over the r ange 4.0-75 mu g ml(-1) of salicylic acid, with a relative standard de viation of less than 1.5% and a sample throughput of 257 h(-1). The in fluence of foreign compounds was studied and the method was applied to the determination of salicylic acid content in two different pharmace utical formulations.