HOW AND WHY CELLS MAKE SUPEROXIDE - THE PHAGOCYTIC NADPH OXIDASE

Authors
MALY FE SCHURERMALY CC
Citation
Fe. Maly et Cc. Schurermaly, HOW AND WHY CELLS MAKE SUPEROXIDE - THE PHAGOCYTIC NADPH OXIDASE, News in physiological sciences, 10, 1995, pp. 233-238
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
10
Year of publication
1995
Pages
233 - 238
Database
ISI
SICI code
0886-1714(1995)10:<233:HAWCMS>2.0.ZU;2-8
Abstract
The phagocyte enzyme NADPH oxidase generates superoxide essential for antimicrobial defense; its genetic defects cause the immunodeficiency disorder chronic granulomatous disease. B lymphocytes and certain othe r nonphagocytes also express NADPH oxidase. Molecular approaches allow new ways to study the enzyme and promise to uncover why nonphagocytic cells express NADPH oxidase.