EFFECT OF ROYAL-JELLY ON SERUM-LIPIDS IN EXPERIMENTAL-ANIMALS AND HUMANS WITH ATHEROSCLEROSIS

The primary objective of this review was to assess the size and consis tency of Royal Jelly (RJ) effect on serum lipids in experimental anima ls and humans. The data from animal studies were pooled, where possibl e, and statistically evaluated by Student's t-test. Meta-analysis was used for the evaluation of human trials. It was found that RJ signific antly decreased serum and liver total lipids and cholesterol levels in rats and rabbits and also retarded the formation of atheromas in the aorta of rabbits fed a hyperlipemic diet. Meta-analysis of the control led human trials of RJ to reduce hyperlipidemia showed a significant r eduction in total serum lipids and cholesterol levels and normalizatio n of HDL and LDL as determined from decrease in beta/alpha lipoprotein s. The best available evidence suggests that RJ at approximately 50 to 100 mg per day, decreased total serum cholesterol levels by about 14% , and total serum lipids by about 10% in the group of patients studied .