THERMOCHEMISTRY OF AQUEOUS-SOLUTIONS OF NUCLEIC-ACID BASES AND THEIR ALKYLATED DERIVATIVES

Enthalpy of solution, Delta H-sol(degrees), enthalpy of sublimation, D elta H-subl(degrees), apparent partial molar volume and heat capacitie s, V-2 degrees and C-p,2(degrees) were determined for aqueous solution s of thirty alkylated derivatives of uracyl and adenine, eight derivat ives of cytosine and guanine. Calculated accessible surface areas and molar volumes are presented, too. The values of enthalpy of solution, enthalpy of sublimation can be useful in the studies on the nature of interaction between these compounds and water molecules. Apparent part ial molar volume and heat capacity give a new aspect on hydrophob prop erties of the examined nucleic acid base derivatives.