FAILURE OF DRUG PENETRATION AND ACQUISITION OF DRUG-RESISTANCE IN CHRONIC TUBERCULOUS EMPYEMA

Authors
ELLIOTT AM BERNING SE ISEMAN MD PELOQUIN CA
Citation
Am. Elliott et al., FAILURE OF DRUG PENETRATION AND ACQUISITION OF DRUG-RESISTANCE IN CHRONIC TUBERCULOUS EMPYEMA, Tubercle and lung disease, 76(5), 1995, pp. 463-467
Citations number
15
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Tubercle and lung disease → ACNP
ISSN journal
09628479
Volume
76
Issue
5
Year of publication
1995
Pages
463 - 467
Database
ISI
SICI code
0962-8479(1995)76:5<463:FODPAA>2.0.ZU;2-E
Abstract
We describe a patient with drug-resistant chronic tuberculous empyema in whom substantial differences between achievable pleural fluid and s erum drug concentrations were displayed, The ratio of maximum concentr ation in pleural fluid to serum was especially low for rifampin (4%) b ut was also low for streptomycin (34%) and ofloxacin (48%). Subtherape utic drug concentrations in the pleural fluid may have contributed to acquisition of drug resistance in this case.