EVALUATION OF CERTAIN UREAS AND NITROSOUREAS OF 2,3-DIHYDRO-1,4-BENZOTHIAZINES AGAINST SARCOMA-180 SOLID TUMORS IN-VIVO

Different derivatives of nitrosoureas were synthesized by a long seque nce of reactions and were evaluated for their anticancer activities ag ainst female Swiss albino mice, 6-8 weeks old, weighing 18-24 g and be aring Sarcoma-180 (S-180) ascitic tumor. Experimental protocols includ e injecting a total of 2 x 10(5) S-180 viable ascitic cells s.c. on da y 0 in the left flank of mice to obtain solid tumors, followed by the treatment of urea/nitrosourea derivatives on days 1, 5 and 9 at differ ent dose levels. Of the 32 compounds tested, eight were found highly a ctive against solid tumors with significant growth delay and tumor wei ght inhibition ratio. B-Fluorouracil was injected s.c. as referent com pound to positive control animals.