CHOLINOTOXIC EFFECTS OF BETA-AMYLOID((1-42)) PEPTIDE ON CORTICAL PROJECTIONS OF THE RAT NUCLEUS BASALIS MAGNOCELLULARIS

Authors
HARKANY T LENGYEL Z SOOS K PENKE B LUITEN PG GULYA K
Citation
T. Harkany et al., CHOLINOTOXIC EFFECTS OF BETA-AMYLOID((1-42)) PEPTIDE ON CORTICAL PROJECTIONS OF THE RAT NUCLEUS BASALIS MAGNOCELLULARIS, Brain research, 695(1), 1995, pp. 71-75
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
695
Issue
1
Year of publication
1995
Pages
71 - 75
Database
ISI
SICI code
0006-8993(1995)695:1<71:CEOBPO>2.0.ZU;2-N
Abstract
beta-Amyloid((1-42)) peptide (beta AP) was injected into the right nuc leus basalis magnocellularis (nbm) of rats. After a 14-day survival ti me, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmatio n of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results dem onstrate the cholinotoxicity of beta AP in an in vivo animal model.