STRUCTURAL SIMILARITY BETWEEN THE PLECKSTRIN HOMOLOGY DOMAIN AND VEROTOXIN - THE PROBLEM OF MEASURING AND EVALUATING STRUCTURAL SIMILARITY

Authors
ORENGO CA SWINDELLS MB MICHIE AD ZVELEBIL MJ DRISCOLL PC WATERFIELD MD THORNTON JM
Citation
Ca. Orengo et al., STRUCTURAL SIMILARITY BETWEEN THE PLECKSTRIN HOMOLOGY DOMAIN AND VEROTOXIN - THE PROBLEM OF MEASURING AND EVALUATING STRUCTURAL SIMILARITY, Protein science, 4(10), 1995, pp. 1977-1983
Citations number
26
Categorie Soggetti
Biology
Journal title
Protein science → ACNP
ISSN journal
09618368
Volume
4
Issue
10
Year of publication
1995
Pages
1977 - 1983
Database
ISI
SICI code
0961-8368(1995)4:10<1977:SSBTPH>2.0.ZU;2-M
Abstract
An unexpected structural similarity is described between the pleckstri n homology (PH) domain and verotoxin. This similarity has escaped dete ction primarily due to the differences in topology that exist between the two proteins, By comparing this result with two previously reporte d similarities for the PH domain, one with the lipocalins and another with the FK506 binding protein, we discuss the problems of measuring a nd assessing structural similarities.