The short-term benefits of hormone replacement therapy (HRT) for the r
elief of acute menopausal symptoms are beyond dispute. It is equally c
lear that premenopausal women who have undergone surgical menopause ne
ed HRT to prevent the otherwise rapid development of coronary heart di
sease and osteoporosis. There is epidemiologic evidence that women who
have undergone a natural menopause receive similar relief with HRT. Y
et patient compliance with long-term HRT is poor. This is due to unacc
eptable uterine bleeding and the largely unfounded fear that HRT promo
tes breast cancer.