Yw. Zhang et al., SEROLOGICAL REACTIVITY AGAINST CYST AND TACHYZOITE ANTIGENS OF TOXOPLASMA-GONDII DETERMINED BY FAST-ELISA, Journal of Clinical Pathology, 48(10), 1995, pp. 908-911
Aims-To obtain quantitative data on the human serological response to
Toxoplasma gondii tachyzoite and bradyzoite antigens. Methods-Serum sa
mples from 30 patients who had positive antibody titres against T gond
ii and from 14 who were seronegative, together with sequential serum s
amples from four infected individuals, were screened by FAST-ELISA. Re
sults-Serum samples from the 30 seropositive patients showed high IgG
and IgM titres against the T gondii tachyzoite antigen but very low re
sponses to cyst antigen. This result was borne out in sequential serum
samples from patients with toxoplasmosis. Conclusion-Antibody recogni
tion of the cystic stage of T gondii is low, implying that either this
stage is poorly immunogenic or that the antigen load is low.