S. Garnierlyonnet et al., CYCLOSPORINE-A IMPROVES SEVERE ATOPIC-DERMATITIS IN ADULTS AND REDUCES ACTIVATED CD4(-LYMPHOCYTES() T), EJD. European journal of dermatology, 5(6), 1995, pp. 481-485
In this study, we report on the efficacity of low and medium dose leve
ls of cyclosporin A in twelve adults suffering from severe atopic derm
atitis. The initial dose of 5 mg/kg/d was reduced as soon as a marked
clinical improvement was obtained in an effort to find the therapeutic
minimal effective dose. After 3 months, the treatment was continued o
nly where there was sufficient day efficacy (improvement > 70%). the t
herapeutic effect on the skin was assessed by 2 biopsies (Day 0-Day 60
in 2 patients). The results showed a very rapid fall in the clinical
severity score after 15 days of treatment in all patients, but with gr
eat variation in the interindividual minimal effective dose. The study
of immunological markers showed a decrease of activated circulating T
4 cells in relation to clinical improvement and biopsies showed a lowe
red activated state (HLA-DR) although T4 cells were still expressed in
the dermis.