FOLLICULAR MYCOSIS-FUNGOIDES - RESPONSE TO TREATMENT WITH INTERFERON ALPHA-2A AND ETRETINATE

A 65-year-old man had a 7-year history of a generalized pruritic erupt ion consisting of widespread follicular hyperkeratosis, comedo-like le sions, acquired epidermal cysts and infiltrated plaques on the face, n eck and hands. He also had diffuse alopecia and xerosis. Findings of h istopathologic and immunohistochemical studies showed atypical CD4(+) T lymphocytes infiltrating the hair follicles with preservation of the epidermis. These findings were consistent with a diagnosis of follicu lar mycosis fungoides. Remission was induced with a combination of int erferon alpha-2a and etretinate.